Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer
نویسندگان
چکیده
منابع مشابه
Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer.
Zinc deficiency (ZD) increases the risk of esophageal squamous cell carcinoma (ESCC). In a rat model, chronic ZD induces an inflammatory gene signature that fuels ESCC development. microRNAs regulate gene expression and are aberrantly expressed in cancers. Here we investigated whether chronic ZD (23 weeks) also induces a protumorigenic microRNA signature. Using the nanoString technology, we eva...
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Zinc deficiency (ZD) increases the risk of esophageal squamous cell carcinoma (ESCC), and marginal ZD is prevalent in humans. In rats, marked-ZD (3 mg Zn/kg diet) induces a proliferative esophagus with a 5-microRNA signature (miR-31, -223, -21, -146b, -146a) and promotes ESCC. Here we report that moderate and mild-ZD (6 and 12 mg Zn/kg diet) also induced esophageal hyperplasia, albeit less pron...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2012
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/bgs204